Migraine is not a simple headache, but a complex neurological disorder. During an attack, the trigeminovascular system becomes overactive, with substances like CGRP (Calcitonin Gene-Related Peptide) and nitric oxide (NO) triggering a cascade of pain, neuroinflammation, and sensory oversensitivity. Light, sound, smell, nausea, and sometimes aura are common accompaniments.

The nervous system is, as it were, tuned too sharply.

It's precisely at this intersection—pain transmission, inflammation, neurotransmitters, and stress regulation—that the endocannabinoid system (ECS) comes into play. And that's precisely where the interest in full-spectrum cannabis extracts , and particularly CBDa-rich oils , arises.