Natural support for hormonal changes

Menopause isn't a disease, but for many women, this phase of life feels anything but natural. Hot flashes, poor sleep, mood swings, joint pain, decreased focus, and changes in libido can significantly impact daily life. While hormone therapy offers relief for some, a growing number of women are looking for more natural, gentler alternatives that support the body instead of taking over.

Within this quest, interest in full-spectrum cannabis extracts is growing, and in particular CBDa (cannabidiolic acid) – the raw, unheated form of CBD. But what makes CBDa so interesting for menopausal symptoms? And what does science have to say about this?

Menopause: More than just hormones

During peri- and postmenopause, estrogen production decreases significantly. This affects not only the reproductive organs but the entire body : the nervous system, bones, metabolism, brain, and immune system.

What is less well known is that estrogen works closely with the endocannabinoid system (ECS) – a natural regulatory system in the body that is involved in, among other things:

• mood and stress

• sleep-wake rhythm

• pain and inflammation

• temperature regulation

• hormonal balance

When estrogen levels drop, ECS activity often decreases as well. This may explain why many menopausal symptoms are so widespread and diffuse. The body literally becomes unbalanced.

Why cannabis extracts may support this

Cannabis contains a rich spectrum of active substances:

• cannabinoids (such as CBDa, CBD, THC, THCa, CBG)

• terpenes (such as linalool, myrcene, and caryophyllene)

• flavonoids (powerful antioxidants)

In a full spectrum extract, these substances work together through the so-called entourage effect : they enhance each other's effects and provide broader, deeper support than isolated substances.

Especially in a complex process such as the transition – in which several systems change simultaneously – this synergy proves essential.

The special role of CBDa (cannabidiolic acid)

CBDa is the biologically active, acidic form of CBD , as found in the raw hemp plant. Unlike CBD, CBDa is not heated (decarboxylated) and retains unique properties that are particularly relevant for menopausal symptoms.

Preclinical research shows, among other things, that CBDa:

• a powerful anti-inflammatory is via COX-2 inhibition

• has an effect on anxiety and mood even in low doses

• influences the serotonin system (5-HT1A) , which is relevant in mood swings

• may play a supporting role in hormonal regulation

For women in menopause – who often experience low-grade inflammation, joint pain, inner turmoil and emotional fluctuations – this makes CBDa particularly interesting.

What does science say so far?

Although large-scale clinical studies in menopausal women are still scarce, evidence is slowly mounting:

• Surveys show that a large percentage of women use cannabis for menopausal symptoms, especially sleep problems, anxiety and mood.

• Animal studies show that CBD may be beneficial for bone density, metabolism, and inflammatory processes in estrogen deficiency.

• Clinical observations by doctors show that CBD (oral and topical) can help with, among other things, heart palpitations, joint pain and vaginal dryness.

• Theoretical models describe how the ECS plays a key role in postmenopausal health, from bones to brain.

The scientific conclusion is cautious but encouraging: cannabinoids appear to help the body regain balance in a phase in which hormonal control decreases.

Full spectrum CBDa oil: why we work with it

At CBD & Herb, we work with CBD Spain , developed by Peter Vermeul , the founder and scientific brain behind these oils. His research focuses not on symptom management, but on system restoration : supporting the ECS so the body can better regulate itself.

Full spectrum CBDa oil:

• preserves the natural composition of the plant

• contains CBDa, other cannabinoids, terpenes and flavonoids

• works subtly, without intoxication

• is suitable for long-term use

It is precisely these properties that make it a valuable option for women who want to support their menopause consciously and naturally .

Finally: an invitation to deepen

Menopause isn't a struggle, but a support system. More and more women are discovering that they don't have to "accept" their symptoms, nor do they have to suppress them with heavy-duty methods. Restoring balance appears to be the key.

This blog is an introduction.
Do you really want to understand how CBDa, the endocannabinoid system, and hormonal changes are linked?
We cordially invite you to read further on our science page , where you can also find Peter Vermeul 's complete research.

👉 Delve into the science behind CBDa – and discover what natural balance for menopausal symptoms can do for you.

• Cannabis Extracts (CBDa) for Menopause - pdf NL
• Cannabis extracts (CBDa) during the transition (Menopause) - pdf EN