Crohn's disease is a chronic, often life-threatening inflammatory disease of the gastrointestinal tract. Abdominal pain, diarrhea, fatigue, weight loss, and fluctuating disease activity define daily life for many people. Despite advances in conventional treatments—such as anti-inflammatories, immunosuppressants, and biologics—a significant group of patients continues to seek additional support. This is not because they are opposed to conventional care, but because it doesn't always provide sufficient relief or is associated with significant side effects.

In this quest, medicinal cannabis is increasingly gaining traction. Full-spectrum cannabis extracts , specifically CBDa-rich and THCa-rich oils , are attracting attention. In this blog post, we'll explore the key insights from research and practice, based on the work and analyses of Peter Vermeul , founder of CBD Spain . The goal: to provide insight into why full-spectrum CBDa oil can be beneficial for Crohn's disease—and why it differs significantly from isolated CBD products.

Crohn's and cannabis: what does science show?

In recent years, a growing number of studies have been published on the use of cannabis for inflammatory bowel disease (IBD), including Crohn's. Clinical trials with THC-rich full-spectrum cannabis show that a significant proportion of patients experience significant symptom improvement. In some studies, nearly half of the participants achieved clinical remission, and some were even able to discontinue corticosteroid use.

What's striking is what happened when researchers tested a CBD isolate : there was no effect. There was no significant improvement in symptoms. This contrast suggests that the therapeutic potential of cannabis for Crohn's disease lies not in a single substance, but rather in the synergy of multiple cannabinoids and plant compounds .

It's important to emphasize that most studies primarily show improvements in symptoms (pain, appetite, sleep, general well-being). The direct impact on the underlying inflammation is less clearly demonstrated. Nevertheless, many patients experience their disease as more manageable and report fewer flare-ups.

The Forgotten Power of Cannabinoid Acids (CBDa and THCa)

What distinguishes full-spectrum extracts from heated or isolated products is the presence of cannabinoids in their natural acid form . In the living plant, cannabinoids do not exist as THC and CBD, but as THCa and CBDa . Only through heating (decarboxylation) do they change into their familiar neutral forms.

THCa: anti-inflammatory without the 'high'

Laboratory research shows that THCa possesses potent anti-inflammatory properties, specifically in intestinal tissue. In vitro models showed a clear inhibition of pro-inflammatory mediators such as IL-8 and COX-2. Remarkably, this effect was stronger than that of isolated CBD. Moreover, THCa is non-psychoactive , making it attractive for those seeking clarity of mind.

CBDa: more than a precursor

CBDa also deserves attention. Preclinical research indicates:

• Anti-inflammatory properties (including via COX-2 inhibition)

• A strong anti-nausea effect via serotonin receptors

• Possible antibacterial effect

This makes CBDa particularly relevant, especially in Crohn's disease – where nausea, loss of appetite and intestinal dysbiosis play a role.

Why full spectrum works: the entourage effect

Full-spectrum extracts contain not only CBDa and THCa, but also other cannabinoid acids (such as CBGa), small amounts of THC and CBD, and terpenes and flavonoids. These substances interact and potentiate each other's effects – a phenomenon known as the entourage effect .

With a complex condition like Crohn's, this is crucial. Different components intervene in different processes:

• Inflammatory pathways in the intestinal wall

• Pain and cramp experience

• Appetite and nausea

• Stress, anxiety and sleep

An isolate can only affect one piece of the puzzle. A truly full-spectrum extract works multimodally .

Dosage forms: oil, suppositories and combinations

In practice, Crohn's patients use various forms of full-spectrum extracts:

Oral (drops or capsules)

• Longer lasting effect

• Suitable for daily maintenance

• Raw (unheated) extract retains CBDa and THCa

Rectal (suppositories)

• Local and systemic effect

• Better absorption of cannabinoid acids

• Barely psychoactive

• Particularly interesting in cases of involvement of the colon or rectum

Many users combine forms: for example, a CBDa-rich oil during the day and a different composition for relaxation and sleep in the evening.

Practical experiences: more quality of life

Patient experiences are a common thread throughout the research. Many people with Crohn's disease report that full-spectrum cannabis extracts make their lives "liveable again." They experience less pain, better sleep, a renewed appetite, and greater control over their own bodies.

At the same time, an important nuance is also apparent: cannabis is not a replacement for conventional care , but a supplement . Anyone who ignores this risks relapse. The greatest benefit appears to lie in collaboration—not opposition.

The vision of Peter Vermeul

According to Peter Vermeul, the key lies in true full-spectrum extracts , preserving cannabinoid acids and supported by independent test reports (CoAs). In a market where "full-spectrum" has often become a marketing term, he advocates for transparency and scientific substantiation.

His work shows that it is precisely the acid forms of cannabinoids , combined with the complete plant profile, that provide a logical explanation for the positive experiences of many Crohn's patients.

Finally

Full-spectrum CBDa oil doesn't offer a miracle cure, but it does offer a promising complementary approach for people with Crohn's disease. The combination of science, practical experience, and the entourage effect makes it clear why more and more patients and therapists are turning to it.

Want to delve deeper into the science, including source references and research details? Then read the full article, which focuses on Peter Vermeul's research.

• Full Spectrum Cannabis Extracts for Crohn's Disease -pdf NL
• Full Spectrum Cannabis extracts for Crohn's disease - pdf EN

CBD & Herb – knowledge, nature and nuance.